Product Description of Amine-Reactive Biotins
Isothiocyanobenzyl-EDTA 通过其胺基将 EDTA 部分添加到蛋白质中。 然后可以用重金属离子和放射性金属（如 111In 和 99Tc）标记 EDTA 标记的蛋白质，并用于免疫成像。
Chemical Structure
1. C. F. Meares and T. G. Wensel, Metal Chelates as Probes of Biological Systems, Acc. Chem. Res.,1984, 17, 202.2. S. V. Deshpande, R. Subramanian, M. J. McCall, S. J. Denardo, G. L. Denardo and C. F. Meares, Metabolism of Indium Chelates Attached to Monoclonal Antibody: Minimal Transchelation of Indium form Benzyl-EDTA Chelate in vivo, J. Nucl. Med., 1990, 31, 218.3. S. Mirzadeh, M. W. Brechbiel and R. W. Atcher, Otto A. Gansow Radiometal Labeling of Immunoproteins: Covalent Linkage of 2-(4-Isothiocyanatobenzyl) diethylenetriaminepentaacetic acid Ligands to Immunoglobulin, Bioconjugate Chem., 1990, 1, 59.