Chlorpromazine HCl

产品描述

Chlorpromazine是一种多巴胺和钾离子通道抑制剂，IC50分别为6.1 和 16 μM。

靶点

IC50

生物活性

Chlorpromazine (Sonazine) is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 µM for nward-rectifying K+ currents and time-independent outward currents.In inhibits prolactin release inhibitory factor, thus stimulating the release of prolactin.  The turnover of dopamine in the brain is also increased. Chlorpromazine blocks a variety of K+ channels in heart muscle cells. Inasmuch as the potency of inhibition is less than the previously reported use-dependent block of Na+ channels, the cardiovascular adverse effects of chlorpromazine are probably caused mainly by the latter effect.

溶解性

DMSO 71 mg/mL，水 71 mg/mL，乙醇 71 mg/mL

稳定性

2年 -20°C粉状，6月-80°C溶于DMSO

特征